HNF4G
hepatocyte nuclear factor 4 gamma
Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome 8 (steroid and nuclear hormone receptors, cell signaling and transcription factors). Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
Hepatocyte nuclear factor 4-gamma
- Function
Transcription factor. Has a lower transcription activation potential than HNF4-alpha.
- Subcellular location
Nucleus.
- Tissue specificity
Expressed in pancreas, kidney, small intestine and testis. Weakly expressed in colon. Not expressed in liver, skeletal muscle, lung, placenta, brain, heart, peripheral blood, ovary, prostate, thymus and spleen.
Source: UniProtKB/Swiss-Prot Q14541, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
Nuclear receptors transduce steroid signals into lasting gene-expression programs; persistent receptor-level remodeling (or silencing) is a leading hypothesis for symptoms that outlast drug exposure. General signaling/transcription machinery; no direct post-drug-syndrome link established for most members — included for completeness of the panel.
Written for the whole nuclear receptors / signaling & transcription family, not for HNF4G specifically.
Mentioned in 0 corpus records
No corpus record names HNF4G directly yet. It is in the library because it sits in a pathway the corpus tracks (Nuclear receptors, Signaling & transcription).
Also in steroid and nuclear hormone receptors
All 41 genes- ARPowers
androgen receptor
chr X· Nuclear receptors· 41 records - ESR1
estrogen receptor 1
chr 6· Nuclear receptors· 1 record - ESR2
estrogen receptor 2
chr 14· Nuclear receptors· Pathway candidate - FOXA1
forkhead box A1
chr 14· Nuclear receptors· Pathway candidate - HNF4A
hepatocyte nuclear factor 4 alpha
chr 20· Nuclear receptors· Pathway candidate - NCOA1
nuclear receptor coactivator 1
chr 2· Nuclear receptors· Pathway candidate - NCOA2
nuclear receptor coactivator 2
chr 8· Nuclear receptors· Pathway candidate - NCOA3
nuclear receptor coactivator 3
chr 20· Nuclear receptors· Pathway candidate
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