Pathway candidateNCBI-verifiedprotein-coding

GJB6

gap junction protein beta 6

NCBI Gene: 10804 Ensembl GeneCards UniProt: O95452

Pathway candidate — not linked to PFS or PSSD by any record here

GJB6 is in the library because it belongs to the sensory & ion channels family. No study, report or commentary in the corpus names it, so a variant in GJB6 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 13 (sensory and ion channels). Gap junctions allow the transport of ions and metabolites between the cytoplasm of adjacent cells. They are formed by two hemichannels, made up of six connexin proteins assembled in groups.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Gap junction beta-6 protein
Function: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular location: Cell membrane; Cell junction, gap junction.
Associated conditions: Ectodermal dysplasia 2, Clouston type (ECTD2); Deafness, autosomal recessive, 1B (DFNB1B); Deafness, autosomal dominant, 3B (DFNA3B).

Source: UniProtKB/Swiss-Prot O95452, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Gap-junction and ion-channel genes; no established post-drug-syndrome link — included for completeness of the panel.

Written for the whole sensory & ion channels family, not for GJB6 specifically.

Mentioned in 0 corpus records

No corpus record names GJB6 directly yet. It is in the library because it sits in a pathway the corpus tracks (Sensory & ion channels).

Also in sensory and ion channels

All 7 genes

Browse by family on the gene families page.

Protein reference (UniProt)

Protein: Gap junction beta-6 protein
Function: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular location: Cell membrane; Cell junction, gap junction.
Associated conditions: Ectodermal dysplasia 2, Clouston type (ECTD2); Deafness, autosomal recessive, 1B (DFNB1B); Deafness, autosomal dominant, 3B (DFNA3B).