Pathway candidateNCBI-verifiedprotein-coding

POU4F3

POU class 4 homeobox 3

NCBI Gene: 5459 Ensembl GeneCards UniProt: Q15319

Pathway candidate — not linked to PFS or PSSD by any record here

POU4F3 is in the library because it belongs to the sensory & ion channels family. No study, report or commentary in the corpus names it, so a variant in POU4F3 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 5 (sensory and ion channels). Encodes a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: POU domain, class 4, transcription factor 3
Function: Acts as a transcriptional activator. Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear (By similarity).
Subcellular location: Nucleus; Cytoplasm.
Tissue specificity: Brain. Seems to be specific to the retina.
Associated conditions: Deafness, autosomal dominant, 15 (DFNA15).

Source: UniProtKB/Swiss-Prot Q15319, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Gap-junction and ion-channel genes; no established post-drug-syndrome link — included for completeness of the panel.

Written for the whole sensory & ion channels family, not for POU4F3 specifically.

Mentioned in 0 corpus records

No corpus record names POU4F3 directly yet. It is in the library because it sits in a pathway the corpus tracks (Sensory & ion channels).

Also in sensory and ion channels

All 7 genes

Browse by family on the gene families page.

Protein reference (UniProt)

Protein: POU domain, class 4, transcription factor 3
Function: Acts as a transcriptional activator. Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear (By similarity).
Subcellular location: Nucleus; Cytoplasm.
Tissue specificity: Brain. Seems to be specific to the retina.
Associated conditions: Deafness, autosomal dominant, 15 (DFNA15).