Pathway candidateNCBI-verifiedprotein-coding

PIEZO1

piezo type mechanosensitive ion channel component 1 (Er blood group)

NCBI Gene: 9780 Ensembl GeneCards UniProt: Q92508

Pathway candidate — not linked to PFS or PSSD by any record here

PIEZO1 is in the library because it belongs to the sensory & ion channels family. No study, report or commentary in the corpus names it, so a variant in PIEZO1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 16 (sensory and ion channels). The protein encoded by this gene is a mechanically-activated ion channel that links mechanical forces to biological signals. The protein contains 36 transmembrane domains and functions as a homotetramer.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Piezo-type mechanosensitive ion channel component 1
Function (excerpt): Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain. Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways. Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium (By similarity). Conductance to monovalent alkali ions is highest for K(+), intermediate for Na(+) and lowest for Li(+). Divalent ions except for Mn(2+) permeate the channel but more slowly than the monovalent ions and they also reduce K(+) currents. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling.
Subcellular location: Endoplasmic reticulum membrane; Endoplasmic reticulum-Golgi intermediate compartment membrane; Cell membrane; Cell projection, lamellipodium membrane.
Tissue specificity: Expressed in numerous tissues. In normal brain, expressed exclusively in neurons, not in astrocytes. In Alzheimer disease brains, expressed in about half of the activated astrocytes located around classical senile plaques. In Parkinson disease substantia nigra, not detected in melanin-containing neurons nor in activated astrocytes. Expressed in erythrocytes (at protein level). Expressed in myoblasts (at protein level).
Associated conditions: Dehydrated hereditary stomatocytosis 1 with or without pseudohyperkalemia and/or perinatal edema (DHS1); Lymphatic malformation 6 (LMPHM6).

Source: UniProtKB/Swiss-Prot Q92508, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Gap-junction and ion-channel genes; no established post-drug-syndrome link — included for completeness of the panel.

Written for the whole sensory & ion channels family, not for PIEZO1 specifically.

Mentioned in 0 corpus records

No corpus record names PIEZO1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Sensory & ion channels).

Also in sensory and ion channels

All 7 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Piezo-type mechanosensitive ion channel component 1
Function (excerpt): Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain. Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways. Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium (By similarity). Conductance to monovalent alkali ions is highest for K(+), intermediate for Na(+) and lowest for Li(+). Divalent ions except for Mn(2+) permeate the channel but more slowly than the monovalent ions and they also reduce K(+) currents. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling.
Subcellular location: Endoplasmic reticulum membrane; Endoplasmic reticulum-Golgi intermediate compartment membrane; Cell membrane; Cell projection, lamellipodium membrane.
Tissue specificity: Expressed in numerous tissues. In normal brain, expressed exclusively in neurons, not in astrocytes. In Alzheimer disease brains, expressed in about half of the activated astrocytes located around classical senile plaques. In Parkinson disease substantia nigra, not detected in melanin-containing neurons nor in activated astrocytes. Expressed in erythrocytes (at protein level). Expressed in myoblasts (at protein level).
Associated conditions: Dehydrated hereditary stomatocytosis 1 with or without pseudohyperkalemia and/or perinatal edema (DHS1); Lymphatic malformation 6 (LMPHM6).