Pathway candidateNCBI-verifiedprotein-coding

GRIN1

glutamate ionotropic receptor NMDA type subunit 1

NCBI Gene: 2902 Ensembl GeneCards UniProt: Q05586

Pathway candidate — not linked to PFS or PSSD by any record here

GRIN1 is in the library because it belongs to the neurotransmission family. No study, report or commentary in the corpus names it, so a variant in GRIN1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 9 (neurotransmission). The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Glutamate receptor ionotropic, NMDA 1
Function: Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the long-term potentiation (LTP). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity). Each GluN2 or GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators.
Subcellular location: Cell membrane; Postsynaptic cell membrane; Postsynaptic density membrane; Synaptic cell membrane.
Associated conditions: Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant (NDHMSD); Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive (NDHMSR); Developmental and epileptic encephalopathy 101 (DEE101).

Source: UniProtKB/Swiss-Prot Q05586, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Monoamine, GABA, glutamate, and cholinergic systems are the direct pharmacologic targets of SSRIs/SNRIs (PSSD) and the downstream effectors of neurosteroid signaling (PFS).

Written for the whole neurotransmission family, not for GRIN1 specifically.

Mentioned in 0 corpus records

No corpus record names GRIN1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Neurotransmission).

Also in neurotransmission

All 54 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Glutamate receptor ionotropic, NMDA 1
Function: Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the long-term potentiation (LTP). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity). Each GluN2 or GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators.
Subcellular location: Cell membrane; Postsynaptic cell membrane; Postsynaptic density membrane; Synaptic cell membrane.
Associated conditions: Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant (NDHMSD); Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive (NDHMSR); Developmental and epileptic encephalopathy 101 (DEE101).