Pathway candidateNCBI-verifiedprotein-coding

LDLR

low density lipoprotein receptor

NCBI Gene: 3949 Ensembl GeneCards UniProt: P01130

Pathway candidate — not linked to PFS or PSSD by any record here

LDLR is in the library because it belongs to the lipid homeostasis family. No study, report or commentary in the corpus names it, so a variant in LDLR is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 19 (lipid and cholesterol homeostasis). The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. The protein is normally bound at the cell membrane, where it binds low density lipoprotein/cholesterol and is taken into the cell.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Low-density lipoprotein receptor
Function: Binds low density lipoprotein /LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Forms a ternary complex with PGRMC1 and TMEM97 receptors which increases LDLR-mediated LDL internalization.
Subcellular location: Cell membrane; Membrane, clathrin-coated pit; Golgi apparatus; Early endosome; Late endosome; Lysosome.
Associated conditions: Hypercholesterolemia, familial, 1 (FHCL1).

Source: UniProtKB/Swiss-Prot P01130, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Cholesterol is the obligate precursor of all steroid hormones; lipid handling sets substrate supply for steroidogenesis and neurosteroid synthesis.

Written for the whole lipid homeostasis family, not for LDLR specifically.

Mentioned in 0 corpus records

No corpus record names LDLR directly yet. It is in the library because it sits in a pathway the corpus tracks (Lipid homeostasis).

Also in lipid and cholesterol homeostasis

All 19 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Low-density lipoprotein receptor
Function: Binds low density lipoprotein /LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Forms a ternary complex with PGRMC1 and TMEM97 receptors which increases LDLR-mediated LDL internalization.
Subcellular location: Cell membrane; Membrane, clathrin-coated pit; Golgi apparatus; Early endosome; Late endosome; Lysosome.
Associated conditions: Hypercholesterolemia, familial, 1 (FHCL1).