Pathway candidateNCBI-verifiedprotein-coding

LIPE

lipase E, hormone sensitive type

NCBI Gene: 3991 Ensembl GeneCards UniProt: Q05469

Pathway candidate — not linked to PFS or PSSD by any record here

LIPE is in the library because it belongs to the lipid homeostasis family. No study, report or commentary in the corpus names it, so a variant in LIPE is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 19 (lipid and cholesterol homeostasis). The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Hormone-sensitive lipase
Function: Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters. Shows a preferential hydrolysis of DAGs over TAGs and MAGs and preferentially hydrolyzes the fatty acid (FA) esters at the sn-3 position of the glycerol backbone in DAGs. Preferentially hydrolyzes FA esters at the sn-1 and sn-2 positions of the glycerol backbone in TAGs (By similarity). Catalyzes the hydrolysis of 2-arachidonoylglycerol, an endocannabinoid and of 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (By similarity). In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production (By similarity).
Pathway: Glycerolipid metabolism; triacylglycerol degradation.
Subcellular location: Cell membrane; Membrane, caveola; Cytoplasm, cytosol; Lipid droplet.
Tissue specificity: Testis.
Associated conditions: Lipodystrophy, familial partial, 6 (FPLD6).

Source: UniProtKB/Swiss-Prot Q05469, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Cholesterol is the obligate precursor of all steroid hormones; lipid handling sets substrate supply for steroidogenesis and neurosteroid synthesis.

Written for the whole lipid homeostasis family, not for LIPE specifically.

Mentioned in 0 corpus records

No corpus record names LIPE directly yet. It is in the library because it sits in a pathway the corpus tracks (Lipid homeostasis).

Also in lipid and cholesterol homeostasis

All 19 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Hormone-sensitive lipase
Function: Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters. Shows a preferential hydrolysis of DAGs over TAGs and MAGs and preferentially hydrolyzes the fatty acid (FA) esters at the sn-3 position of the glycerol backbone in DAGs. Preferentially hydrolyzes FA esters at the sn-1 and sn-2 positions of the glycerol backbone in TAGs (By similarity). Catalyzes the hydrolysis of 2-arachidonoylglycerol, an endocannabinoid and of 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (By similarity). In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production (By similarity).
Pathway: Glycerolipid metabolism; triacylglycerol degradation.
Subcellular location: Cell membrane; Membrane, caveola; Cytoplasm, cytosol; Lipid droplet.
Tissue specificity: Testis.
Associated conditions: Lipodystrophy, familial partial, 6 (FPLD6).