Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome 15 (lipid and cholesterol homeostasis). The protein encoded by this gene coats lipid storage droplets in adipocytes, thereby protecting them until they can be broken down by hormone-sensitive lipase. The protein is the major cAMP-dependent protein kinase substrate in adipocytes and, when unphosphorylated, may play a role in the inhibition of lipolysis.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
Perilipin-1
- Function
Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels.
- Subcellular location
Endoplasmic reticulum; Lipid droplet.
- Tissue specificity
Detected in adipocytes from white adipose tissue (at protein level). Detected in visceral adipose tissue and mammary gland.
- Associated conditions
Lipodystrophy, familial partial, 4 (FPLD4).
Source: UniProtKB/Swiss-Prot O60240, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
Cholesterol is the obligate precursor of all steroid hormones; lipid handling sets substrate supply for steroidogenesis and neurosteroid synthesis.
Written for the whole lipid homeostasis family, not for PLIN1 specifically.
Mentioned in 0 corpus records
No corpus record names PLIN1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Lipid homeostasis).
Also in lipid and cholesterol homeostasis
All 19 genes- LRP2
LDL receptor related protein 2
chr 2· Lipid homeostasis· 4 records - APOA1
apolipoprotein A1
chr 11· Lipid homeostasis· Pathway candidate - APOB
apolipoprotein B
chr 2· Lipid homeostasis· Pathway candidate - CUBN
cubilin
chr 10· Lipid homeostasis· Pathway candidate - DGAT1
diacylglycerol O-acyltransferase 1
chr 8· Lipid homeostasis· Pathway candidate - DGAT2
diacylglycerol O-acyltransferase 2
chr 11· Lipid homeostasis· Pathway candidate - FABP4
fatty acid binding protein 4
chr 8· Lipid homeostasis· Pathway candidate - FABP5
fatty acid binding protein 5
chr 8· Lipid homeostasis· Pathway candidate
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