POLR2E
RNA polymerase II, I and III subunit E
Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome 19 (basal transcription machinery). Encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
DNA-directed RNA polymerases I, II, and III subunit RPABC1
- Function
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPABC1 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template.
- Subcellular location
Nucleus; Nucleus, nucleolus.
Source: UniProtKB/Swiss-Prot P19388, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
Core RNA polymerase II machinery; general cellular function with no direct post-drug-syndrome link established.
Written for the whole basal transcription family, not for POLR2E specifically.
Mentioned in 0 corpus records
No corpus record names POLR2E directly yet. It is in the library because it sits in a pathway the corpus tracks (Basal transcription).
Also in basal transcription machinery
All 27 genes- GTF2A1
general transcription factor IIA subunit 1
chr 14· Basal transcription· Pathway candidate - GTF2B
general transcription factor IIB
chr 1· Basal transcription· Pathway candidate - GTF2E1
general transcription factor IIE subunit 1
chr 3· Basal transcription· Pathway candidate - GTF2F1
general transcription factor IIF subunit 1
chr 19· Basal transcription· Pathway candidate - GTF2H1
general transcription factor IIH subunit 1
chr 11· Basal transcription· Pathway candidate - POLR2A
RNA polymerase II subunit A
chr 17· Basal transcription· Pathway candidate - POLR2B
RNA polymerase II subunit B
chr 4· Basal transcription· Pathway candidate - POLR2C
RNA polymerase II subunit C
chr 16· Basal transcription· Pathway candidate
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