POLR2I
RNA polymerase II subunit I
Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome 19 (basal transcription machinery). Encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with two other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
DNA-directed RNA polymerase II subunit RPB9
- Function
Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. POLR2I/RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template.
- Subcellular location
Nucleus, nucleolus.
Source: UniProtKB/Swiss-Prot P36954, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
Core RNA polymerase II machinery; general cellular function with no direct post-drug-syndrome link established.
Written for the whole basal transcription family, not for POLR2I specifically.
Mentioned in 0 corpus records
No corpus record names POLR2I directly yet. It is in the library because it sits in a pathway the corpus tracks (Basal transcription).
Also in basal transcription machinery
All 27 genes- GTF2A1
general transcription factor IIA subunit 1
chr 14· Basal transcription· Pathway candidate - GTF2B
general transcription factor IIB
chr 1· Basal transcription· Pathway candidate - GTF2E1
general transcription factor IIE subunit 1
chr 3· Basal transcription· Pathway candidate - GTF2F1
general transcription factor IIF subunit 1
chr 19· Basal transcription· Pathway candidate - GTF2H1
general transcription factor IIH subunit 1
chr 11· Basal transcription· Pathway candidate - POLR2A
RNA polymerase II subunit A
chr 17· Basal transcription· Pathway candidate - POLR2B
RNA polymerase II subunit B
chr 4· Basal transcription· Pathway candidate - POLR2C
RNA polymerase II subunit C
chr 16· Basal transcription· Pathway candidate
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