POLR2J
RNA polymerase II subunit J
Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome 7 (basal transcription machinery). Encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene exists as a heterodimer with another polymerase subunit; together they form a core subassembly unit of the polymerase.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
DNA-directed RNA polymerase II subunit RPB11-a
- Function
Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates.
- Subcellular location
Nucleus.
- Tissue specificity
Ubiquitously expressed. High expression was found in heart and skeletal muscle.
Source: UniProtKB/Swiss-Prot P52435, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
Core RNA polymerase II machinery; general cellular function with no direct post-drug-syndrome link established.
Written for the whole basal transcription family, not for POLR2J specifically.
Mentioned in 0 corpus records
No corpus record names POLR2J directly yet. It is in the library because it sits in a pathway the corpus tracks (Basal transcription).
Also in basal transcription machinery
All 27 genes- GTF2A1
general transcription factor IIA subunit 1
chr 14· Basal transcription· Pathway candidate - GTF2B
general transcription factor IIB
chr 1· Basal transcription· Pathway candidate - GTF2E1
general transcription factor IIE subunit 1
chr 3· Basal transcription· Pathway candidate - GTF2F1
general transcription factor IIF subunit 1
chr 19· Basal transcription· Pathway candidate - GTF2H1
general transcription factor IIH subunit 1
chr 11· Basal transcription· Pathway candidate - POLR2A
RNA polymerase II subunit A
chr 17· Basal transcription· Pathway candidate - POLR2B
RNA polymerase II subunit B
chr 4· Basal transcription· Pathway candidate - POLR2C
RNA polymerase II subunit C
chr 16· Basal transcription· Pathway candidate
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