Pathway candidateNCBI-verifiedprotein-coding

RBP1

retinol binding protein 1

NCBI Gene: 5947 Ensembl GeneCards UniProt: P09455

Pathway candidate — not linked to PFS or PSSD by any record here

RBP1 is in the library because it belongs to the retinoid signaling family. No study, report or commentary in the corpus names it, so a variant in RBP1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 3 (retinoid signaling). This gene encodes the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. Multiple transcript variants encoding different isoforms have been found for this gene.

Source: NCBI Gene and Ensembl, accessed 2026-10-11.

Protein reference (UniProt)

Protein: Retinol-binding protein 1
Function: Cytoplasmic retinol-binding protein. Accepts retinol from the transport protein STRA6, and thereby contributes to retinol uptake, storage and retinoid homeostasis.
Subcellular location: Cytoplasm; Lipid droplet.
Tissue specificity: Detected in nearly all the tissues with higher expression in adult ovary, pancreas, pituitary gland and adrenal gland, and fetal liver.

Source: UniProtKB/Swiss-Prot P09455, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

These proteins take vitamin A from blood to gene regulation: RBP4 carries retinol, STRA6 takes it into cells, LRAT stores it, RDH10 and the ALDH1A enzymes turn it into retinoic acid (DHRS3 reverses the first step), CRABP2 carries retinoic acid to the nucleus, the RAR and RXR receptors act on it, and CYP26A1 and CYP26B1 break it down. Isotretinoin, the drug behind post-retinoid sexual dysfunction, is a retinoid; and several retinol dehydrogenases (RDH16, HSD17B6, RDH5) also oxidize androgen metabolites such as 3α-androstanediol, a point of contact with the steroid pathways implicated in PFS.

Written for the whole retinoid signaling family, not for RBP1 specifically.

Mentioned in 0 corpus records

No corpus record names RBP1 directly yet. It is in the library because it sits in a pathway the corpus tracks (retinoid signaling).

Also in retinoid signaling

All 23 genes

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Gene summary

Source: NCBI Gene and Ensembl, accessed 2026-10-11.

Protein reference (UniProt)

Protein: Retinol-binding protein 1
Function: Cytoplasmic retinol-binding protein. Accepts retinol from the transport protein STRA6, and thereby contributes to retinol uptake, storage and retinoid homeostasis.
Subcellular location: Cytoplasm; Lipid droplet.
Tissue specificity: Detected in nearly all the tissues with higher expression in adult ovary, pancreas, pituitary gland and adrenal gland, and fetal liver.

Why its pathway is in the library

Written for the whole retinoid signaling family, not for RBP1 specifically.