RDH10
retinol dehydrogenase 10
Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome 8 (retinoid signaling). This gene encodes a retinol dehydrogenase, which converts all-trans-retinol to all-trans-retinal, with preference for NADP as a cofactor. Studies in mice suggest that this protein is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development.
Source: NCBI Gene and Ensembl, accessed 2026-10-11.
Protein reference (UniProt)
- Protein
Retinol dehydrogenase 10
- Function
Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol.
- Pathway
Cofactor metabolism; retinol metabolism.
- Subcellular location
Microsome membrane; Endoplasmic reticulum membrane.
- Tissue specificity
Detected in retina, kidney, liver, small intestine, placenta, lung, heart and skeletal muscle.
Source: UniProtKB/Swiss-Prot Q8IZV5, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
These proteins take vitamin A from blood to gene regulation: RBP4 carries retinol, STRA6 takes it into cells, LRAT stores it, RDH10 and the ALDH1A enzymes turn it into retinoic acid (DHRS3 reverses the first step), CRABP2 carries retinoic acid to the nucleus, the RAR and RXR receptors act on it, and CYP26A1 and CYP26B1 break it down. Isotretinoin, the drug behind post-retinoid sexual dysfunction, is a retinoid; and several retinol dehydrogenases (RDH16, HSD17B6, RDH5) also oxidize androgen metabolites such as 3α-androstanediol, a point of contact with the steroid pathways implicated in PFS.
Written for the whole retinoid signaling family, not for RDH10 specifically.
Mentioned in 0 corpus records
No corpus record names RDH10 directly yet. It is in the library because it sits in a pathway the corpus tracks (retinoid signaling).
Also in retinoid signaling
All 23 genes- AKR1C3Powers
aldo-keto reductase family 1 member C3
chr 10· Steroid synthesis· 9 records - ALDH1A1
aldehyde dehydrogenase 1 family member A1
chr 9· Drug metabolism· Pathway candidate - ALDH1A2
aldehyde dehydrogenase 1 family member A2
chr 15· Drug metabolism· Pathway candidate - ALDH1A3
aldehyde dehydrogenase 1 family member A3
chr 15· retinoid signaling· Pathway candidate - CRABP2
cellular retinoic acid binding protein 2
chr 1· retinoid signaling· Pathway candidate - CYP26A1
cytochrome P450 family 26 subfamily A member 1
chr 10· retinoid signaling· Pathway candidate - CYP26B1
cytochrome P450 family 26 subfamily B member 1
chr 2· retinoid signaling· Pathway candidate - CYP2C8
cytochrome P450 family 2 subfamily C member 8
chr 10· retinoid signaling· Pathway candidate
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