Pathway candidateNCBI-verifiedprotein-coding

SCARB1

scavenger receptor class B member 1

NCBI Gene: 949 Ensembl GeneCards UniProt: Q8WTV0

Pathway candidate — not linked to PFS or PSSD by any record here

SCARB1 is in the library because it belongs to the lipid homeostasis family. No study, report or commentary in the corpus names it, so a variant in SCARB1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 12 (lipid and cholesterol homeostasis). The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The protein mediates cholesterol transfer to and from HDL.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Scavenger receptor class B member 1
Function: Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity.
Subcellular location: Cell membrane; Membrane, caveola.
Tissue specificity: Widely expressed.

Source: UniProtKB/Swiss-Prot Q8WTV0, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Cholesterol is the obligate precursor of all steroid hormones; lipid handling sets substrate supply for steroidogenesis and neurosteroid synthesis.

Written for the whole lipid homeostasis family, not for SCARB1 specifically.

Mentioned in 0 corpus records

No corpus record names SCARB1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Lipid homeostasis).

Also in lipid and cholesterol homeostasis

All 19 genes

Browse by family on the gene families page.

Protein reference (UniProt)

Protein: Scavenger receptor class B member 1
Function: Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity.
Subcellular location: Cell membrane; Membrane, caveola.
Tissue specificity: Widely expressed.