Pathway candidateNCBI-verifiedprotein-coding

SIGMAR1

sigma receptor chaperone 1

NCBI Gene: 10280 Ensembl GeneCards UniProt: Q99720

Pathway candidate — not linked to PFS or PSSD by any record here

SIGMAR1 is in the library because it belongs to the neurotransmission family. No study, report or commentary in the corpus names it, so a variant in SIGMAR1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 9 (neurotransmission). Encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Sigma non-opioid intracellular receptor 1
Function (excerpt): Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration. Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria.
Subcellular location: Nucleus inner membrane; Nucleus outer membrane; Nucleus envelope; Cytoplasmic vesicle; Endoplasmic reticulum membrane; Membrane; Lipid droplet; Cell junction; Cell membrane; Cell projection, growth cone; Postsynaptic density membrane.
Tissue specificity: Widely expressed with higher expression in liver, colon, prostate, placenta, small intestine, heart and pancreas. Expressed in the retina by retinal pigment epithelial cells. Expressed in alpha-motor neurons.
Associated conditions: Amyotrophic lateral sclerosis 16, juvenile (ALS16); Neuronopathy, distal hereditary motor, autosomal recessive 2 (HMNR2).

Source: UniProtKB/Swiss-Prot Q99720, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Monoamine, GABA, glutamate, and cholinergic systems are the direct pharmacologic targets of SSRIs/SNRIs (PSSD) and the downstream effectors of neurosteroid signaling (PFS).

Written for the whole neurotransmission family, not for SIGMAR1 specifically.

Mentioned in 0 corpus records

No corpus record names SIGMAR1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Neurotransmission).

Also in neurotransmission

All 54 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Sigma non-opioid intracellular receptor 1
Function (excerpt): Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration. Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria.
Subcellular location: Nucleus inner membrane; Nucleus outer membrane; Nucleus envelope; Cytoplasmic vesicle; Endoplasmic reticulum membrane; Membrane; Lipid droplet; Cell junction; Cell membrane; Cell projection, growth cone; Postsynaptic density membrane.
Tissue specificity: Widely expressed with higher expression in liver, colon, prostate, placenta, small intestine, heart and pancreas. Expressed in the retina by retinal pigment epithelial cells. Expressed in alpha-motor neurons.
Associated conditions: Amyotrophic lateral sclerosis 16, juvenile (ALS16); Neuronopathy, distal hereditary motor, autosomal recessive 2 (HMNR2).