Pathway candidateNCBI-verifiedprotein-coding

SOAT2

sterol O-acyltransferase 2

NCBI Gene: 8435 Ensembl GeneCards UniProt: O75908

Pathway candidate — not linked to PFS or PSSD by any record here

SOAT2 is in the library because it belongs to the lipid homeostasis family. No study, report or commentary in the corpus names it, so a variant in SOAT2 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 12 (lipid and cholesterol homeostasis). Summary:This gene is a member of a small family of acyl coenzyme A:cholesterol acyltransferases. The gene encodes a membrane-bound enzyme localized in the endoplasmic reticulum that produces intracellular cholesterol esters from long-chain fatty acyl CoA and cholesterol.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Sterol O-acyltransferase 2
Function: Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) and linolenoyl-CoA ((9Z,12Z,15Z)-octadecatrienoyl-CoA) as substrates. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.
Subcellular location: Endoplasmic reticulum membrane.
Tissue specificity: Expression seems confined in hepatocytes and enterocytes.

Source: UniProtKB/Swiss-Prot O75908, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Cholesterol is the obligate precursor of all steroid hormones; lipid handling sets substrate supply for steroidogenesis and neurosteroid synthesis.

Written for the whole lipid homeostasis family, not for SOAT2 specifically.

Mentioned in 0 corpus records

No corpus record names SOAT2 directly yet. It is in the library because it sits in a pathway the corpus tracks (Lipid homeostasis).

Also in lipid and cholesterol homeostasis

All 19 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Sterol O-acyltransferase 2
Function: Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) and linolenoyl-CoA ((9Z,12Z,15Z)-octadecatrienoyl-CoA) as substrates. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.
Subcellular location: Endoplasmic reticulum membrane.
Tissue specificity: Expression seems confined in hepatocytes and enterocytes.