Post-Finasteride Syndrome And Post-SSRI Sexual Dysfunction: Two Clinical Conditions Apparently Distant, But Very Close
Giatti, Silvia; Diviccaro, Silvia; Cioffi, Lucia; Melcangi, Roberto Cosimo
Frontiers in Neuroendocrinology · 722024
Abstract (paraphrased)
Argues PFS and PSSD share overlapping clinical features (sexual dysfunction, psychological complaints, sleep disorders) and likely common mechanisms involving neuroactive steroids, serotonin/dopamine/catecholamine signaling and gut microbiota, possibly converging on enzymes such as phenylethanolamine N-methyltransferase.
Plain-language summary (paraphrased)
Researchers from the University of Milan make the case that PFS and PSSD are two sides of the same coin. Despite the drugs being totally different, both conditions show the same pattern of lasting sexual, mood and sleep problems — pointing to shared downstream damage in brain steroids, neurotransmitters and gut bacteria.
Why it’s in the corpus
The key bridge paper linking PFS and PSSD pharmacologically; justifies treating them as related post-drug syndromes in one corpus.
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
Related records
- Peer-reviewed paper
Post-finasteride syndrome and post-SSRI sexual dysfunction: two sides of the same coin?
Giatti, Silvia; Diviccaro, Silvia; Panzica, Giancarlo; Melcangi, Roberto Cosimo · Endocrine · 61(2):180-193
A review by the Milan group of post-SSRI sexual dysfunction and post-finasteride syndrome, which share symptoms that persist after the drug is stopped: a felt disconnection between brain and penis, loss of libido and sex drive, difficulty with erection and…
PFS-0062018PFSPSSDCore corpus - Peer-reviewed paperPSSD Discord pick
Post-SSRI Sexual Dysfunction (PSSD): A comprehensive review of epidemiology, pathophysiology, and clinical management
Xie, M.; Huang, P.; Wang, S.; Ma, J.; Zeng, Y.; Sun, J. · Journal (SAGE; 2026)
Systematic review (PubMed/Web of Science/Scopus to April 2024) finding persistent symptoms in up to 74% of affected cohorts beyond 6 months; pathophysiology multifactorial — 5-HT1A desensitization, neurosteroid (allopregnanolone) depletion via 5α-reductase…
HTR1APSSD-0032026PFSPSSDCore corpus - Peer-reviewed paper
Post-finasteride syndrome: a surmountable challenge for clinicians
Traish, Abdulmaged M. · Fertility and Sterility · 113(1):21-50
Systematic evaluation of 250+ articles (1989–2019) on finasteride/dutasteride concludes PFS is a real constellation of persistent sexual, neurological, physical and mental effects in a susceptible subset, proposing endocrine disruption plus epigenetic…
PFS-0012020PFSCore corpus