Does finasteride treatment for benign prostatic hyperplasia influence sperm DNA integrity in dogs?
Daniel de Souza Ramos Angrimani, Luana de Cássia Bicudo, Núria Llamas Luceño, Bruno Rogério Rui, Matheus F. Silva, João Diego de Agostini Losano
Basic and Clinical Andrology2020
Summary (paraphrased)
Canine study asking whether finasteride treatment for benign prostatic hyperplasia alters sperm DNA integrity in dogs. Tests 5-ARI effects on germline DNA — the transgenerational-persistence angle.
Why it’s in the corpus
Germline DNA-integrity effects would be the strongest form of "persistence" (transgenerational). Animal model and DNA integrity rather than methylation — included as a boundary datapoint for the epigenetics question, not as core evidence.
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