Epigenetic Mechanisms of Depression and Antidepressant Action
Vincent Vialou, Jian Feng, Alfred Jay Robison, Eric J. Nestler
Annual Review of Pharmacology and Toxicology2013
Summary (paraphrased)
Landmark review (Nestler lab) establishing that antidepressants act through epigenetic mechanisms — histone modifications and DNA methylation in reward and mood circuitry — producing lasting changes in gene expression. The foundational plausibility argument that psychiatric drugs routinely remodel the brain epigenome.
Why it’s in the corpus
The plausibility backbone for epigenetic persistence on the PSSD axis: if therapeutic antidepressant action itself requires lasting epigenetic remodeling, persistent epigenetic side-effects after discontinuation are mechanistically unsurprising.
Related records
- Peer-reviewed paper
Epigenetics of the Depressed Brain: Role of Histone Acetylation and Methylation
HaoSheng Sun, Pamela Kennedy, Eric J. Nestler · Neuropsychopharmacology
Review of histone acetylation and methylation mechanisms in the depressed brain (Nestler lab). Covers HDAC-dependent and histone-methylation-dependent regulation of mood-relevant gene expression — the chromatin-level mechanisms antidepressants engage.
EPI-0122013PSSDEpigenetics supplement · Oct 2026 - Peer-reviewed paper
Neurosteroids Involvement in the Epigenetic Control of Memory Formation and Storage
Alessandra Colciago; Valerio Magnaghi · Neural Plasticity
Memory formation depends on strengthening synaptic connections in areas like the hippocampus, and the proteins involved are tightly regulated by DNA methylation and histone modifications. This review argues that neurosteroids participate in this epigenetic…
LIT-0592016Literature sweep · Oct 2026 - Video
PSSD and PFS: The Overlooked Syndromes No One Warns You About
Dr. Sanil Rege (consultant psychiatrist) · Dr. Rege · 23:37 (1417s)
PFS/PSSD shared mechanisms; clinical overview; treatment avenues
YT-CZATt5AoQjw2024-07-03PFSPSSDCore corpus