Epigenetic Neuropharmacology: Drugs Affecting the Epigenome in the Brain
Miklós Tóth
Annual Review of Pharmacology and Toxicology2021
Summary (paraphrased)
Review of how CNS-active drugs alter the brain epigenome — covering antidepressants among other drug classes. Generalizes the "psychiatric drugs remodel brain epigenetics" thesis beyond depression to neuropharmacology at large.
Why it’s in the corpus
Generalizes EPI-011's thesis: brain-epigenome remodeling is a routine drug effect, not an edge case — the broadest plausibility support for persistent post-drug epigenetic states across all three syndrome axes.
Related records
- Peer-reviewed paper
Epigenetic Mechanisms of Depression and Antidepressant Action
Vincent Vialou, Jian Feng, Alfred Jay Robison, Eric J. Nestler · Annual Review of Pharmacology and Toxicology
Landmark review (Nestler lab) establishing that antidepressants act through epigenetic mechanisms — histone modifications and DNA methylation in reward and mood circuitry — producing lasting changes in gene expression. The foundational plausibility argument…
EPI-0112013PSSDEpigenetics supplement · Oct 2026