Genotoxicity and DNA Damage in Long-Term SSRI Therapy: A Review Across SSRIs With Citalopram as a Case Study
Emadeldin M. Kamel, Sally Mostafa Khadrawy, Nour Y. S. Yassin, Noha A. Ahmed
Journal of Applied Toxicology2026
Summary (paraphrased)
Review of genotoxicity and DNA damage reported across SSRIs in long-term therapy, with citalopram as a detailed case study. Surveys the evidence that chronic SSRI exposure produces DNA-level damage.
Why it’s in the corpus
DNA damage is a persistence-adjacent mechanism on the PSSD axis: if chronic SSRI exposure damages DNA, downstream epigenetic/repair landscapes change with it. Newest item in this supplement (2026) — postdates the main sweep's PSSD axis.
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