Epigenetics of the Depressed Brain: Role of Histone Acetylation and Methylation
HaoSheng Sun, Pamela Kennedy, Eric J. Nestler
Neuropsychopharmacology2013
Summary (paraphrased)
Review of histone acetylation and methylation mechanisms in the depressed brain (Nestler lab). Covers HDAC-dependent and histone-methylation-dependent regulation of mood-relevant gene expression — the chromatin-level mechanisms antidepressants engage.
Why it’s in the corpus
Chromatin-mechanism background for the PSSD axis: histone-level regulation is the other half (besides DNA methylation) of the epigenetic persistence story, and HDAC pathways are pharmacologically targetable — a treatment-research pointer.
Related records
- Peer-reviewed paper
Epigenetic Mechanisms of Depression and Antidepressant Action
Vincent Vialou, Jian Feng, Alfred Jay Robison, Eric J. Nestler · Annual Review of Pharmacology and Toxicology
Landmark review (Nestler lab) establishing that antidepressants act through epigenetic mechanisms — histone modifications and DNA methylation in reward and mood circuitry — producing lasting changes in gene expression. The foundational plausibility argument…
EPI-0112013PSSDEpigenetics supplement · Oct 2026