The pathophysiology of Post SSRI Sexual Dysfunction – Lessons from a case study
Samantha Klaas; Jessica Barbut Siva; Maarten Bak; Mark Govers; Rudy Schreiber
Biomedicine & Pharmacotherapy2023
Summary (paraphrased)
The authors present a detailed PSSD case and use it to walk through candidate biological mechanisms for the syndrome, noting that although regulators now recognize PSSD, it remains poorly understood, underdiagnosed, and undertreated. The discussion surveys serotonergic, dopaminergic, hormonal, and neurosteroid pathways that could plausibly sustain sexual dysfunction after the drug is gone. The paper argues that clinician familiarity with the symptom pattern is a prerequisite for both diagnosis and future mechanistic research.
Why it’s in the corpus
A recent, accessible synthesis of hypothesized PSSD mechanisms anchored in a case. Useful as the corpus's pathophysiology overview for non-specialists.
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