Post-SSRI Sexual Dysfunction: A Literature Review
Bala, Areeg; Nguyen, Hoang Minh Tue; Hellstrom, Wayne J. G.
Sexual Medicine Reviews · 6(1):29-342018
Abstract (paraphrased)
Comprehensive review of PSSD covering symptoms (genital anesthesia, pleasureless orgasm, low libido, ED), proposed mechanisms (epigenetic gene expression, 5-HT1A downregulation, dopamine-serotonin interactions, hormonal changes, serotonin neurotoxicity) and the lack of definitive treatment.
Plain-language summary (paraphrased)
The standard urology literature review defining PSSD: sexual side effects — especially genital numbness and pleasureless orgasm — that continue after stopping antidepressants. It lays out the leading biological theories, from permanently desensitized serotonin receptors to epigenetic changes, and notes that no proven treatment exists.
Why it’s in the corpus
Core PSSD definitional review; catalogs the mechanistic hypotheses (including epigenetics and neurosteroids) that parallel PFS.
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
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