Re: Why does calcium d glucarate cause anxiety…

Answer to why calcium D-glucarate causes anxiety. Powers explains it downstream of his core model: buildup of two identified neurosteroids produces chronic GABA-A positive allosteric modulation — like constant endogenous Xanax — forcing downstream systems (5-HT2C, 5-HT1A, etc.) to rewire their gain; drugs acting on those receptors can then improve or worsen symptoms without touching the root cause. He mentions roflumilast as a symptom-level "gain knob" that helps some PSSD patients but doesn't fix the underlying problem, and says he hunts backward to the origin instead. He illustrates phenotype heterogeneity: some PSSD patients have only genital numbness with normal libido, others normal sensation with erectile/orgasm dysfunction, others wiped-out libido and substance resistance — likely "compartment locking" or brain-region-specific effects from subtle genetic differences (not every patient has the same glitches). He's beginning to recognize patterns as he accumulates genomic data, using broad phenotype labels (androgenic signal loss, anhedonia, substance resistance, melty) while admitting he can't yet map exact genetic patterns to them.