Re: I collect more and more labsgenomedutch tests…
u/drwillpowers
r/DrWillPowers~6 months ago
Dr Will Powers’ own statements and theorizing
Summary (paraphrased)
Powers argues that PFS patients do not lack 5α-reductase — at baseline the enzyme is upregulated, with DUTCH tests often showing a shunt toward 5α metabolites — calling the popular understanding of the disease the inverse of the actual mechanism. He explains finasteride as a suicide inhibitor: each drug-bound enzyme copy is destroyed, the body regenerates new copies (generally within about 21 days), but that long interval without the body's main androgen exit pathway is what triggers the disease in susceptible people. He frames susceptibility as defective clearance "highways" — UGT defects, SLCO and ABCC variants — that force reliance on the one remaining route the drug then shuts down. He extends the model to minoxidil sensitivity (possible ABCC-mediated intracellular accumulation) and claims the molecular understanding now lets him predict individual substance responses from genomes.
Key points (paraphrased)
- 5AR is upregulated at baseline in PFS (not deficient); DUTCH often shows a 5α shunt — the standard narrative inverted.
- Suicide inhibition: each bound enzyme copy is destroyed; regeneration takes roughly 21 days.
- The ~21-day gap without the main androgen exit pathway is framed as the triggering catastrophe.
- Susceptibility = defective clearance "highways" (UGT/SLCO/ABCC) forcing reliance on the 5AR route.
- Extension to minoxidil sensitivity via ABCC; genome-based substance-response prediction claimed.
Why it’s in the corpus
The mechanism of the triggering event — the "suicide inhibition + 21-day gap" catastrophe model — and the inversion of the standard 5AR-deficiency narrative. It also introduces the highway/gridlock framing of susceptibility that recurs across the tranche.
Context — the post Powers was replying toVerbatim third-party text, shown for context only — not Powers’ statement. Usernames removed.ShowHide
Powers' comment replies to [username removed], who asked supportive follow-up questions: whether 5AR enzymes can regenerate after suicide inhibition, and whether clearing the accumulated metabolites is the key therapeutic step.
(Parent context recovered from the r.genit.al mirror on 2026-10-09; Powers' comment text itself is from John's user-provided export.)
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
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