Persistent sexual dysfunction after discontinuation of selective serotonin reuptake inhibitors
Csoka, Antonei B.; Bahrick, Audrey; Mehtonen, Olavi-Pekka
The Journal of Sexual Medicine · 5(1):227-2332008
Abstract (paraphrased)
Case reports of persistent sexual dysfunction (including genital anesthesia and ejaculatory anhedonia) lasting years after SSRI/SNRI discontinuation in previously healthy individuals; proposes medication-induced changes in gene expression as the mechanism.
Plain-language summary (paraphrased)
One of the earliest medical reports of PSSD, describing patients whose sexual function never returned to normal years after stopping antidepressants. The authors were among the first to suggest the drugs might cause lasting changes in how genes are expressed.
Why it’s in the corpus
Foundational PSSD case evidence; introduced the epigenetic hypothesis for persistent post-drug sexual dysfunction.
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
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