CYP2C8
cytochrome P450 family 2 subfamily C member 8
Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome 10 (retinoid signaling). This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital.
Source: NCBI Gene and Ensembl, accessed 2026-10-11.
Protein reference (UniProt)
- Protein
Cytochrome P450 2C8
- Function
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Primarily catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) with a preference for the last double bond. Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes all trans-retinoic acid toward its 4-hydroxylated form. Displays 16-alpha hydroxylase activity toward estrogen steroid hormones, 17beta-estradiol (E2) and estrone (E1). Plays a role in the oxidative metabolism of xenobiotics. It is the principal enzyme responsible for the metabolism of the anti-cancer drug paclitaxel (taxol).
- Pathway
Steroid metabolism. Lipid metabolism; arachidonate metabolism. Cofactor metabolism; retinol metabolism.
- Subcellular location
Endoplasmic reticulum membrane; Microsome membrane.
Source: UniProtKB/Swiss-Prot P10632, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
These proteins take vitamin A from blood to gene regulation: RBP4 carries retinol, STRA6 takes it into cells, LRAT stores it, RDH10 and the ALDH1A enzymes turn it into retinoic acid (DHRS3 reverses the first step), CRABP2 carries retinoic acid to the nucleus, the RAR and RXR receptors act on it, and CYP26A1 and CYP26B1 break it down. Isotretinoin, the drug behind post-retinoid sexual dysfunction, is a retinoid; and several retinol dehydrogenases (RDH16, HSD17B6, RDH5) also oxidize androgen metabolites such as 3α-androstanediol, a point of contact with the steroid pathways implicated in PFS.
Written for the whole retinoid signaling family, not for CYP2C8 specifically.
Mentioned in 0 corpus records
No corpus record names CYP2C8 directly yet. It is in the library because it sits in a pathway the corpus tracks (retinoid signaling).
Also in retinoid signaling
All 23 genes- AKR1C3Powers
aldo-keto reductase family 1 member C3
chr 10· Steroid synthesis· 9 records - ALDH1A1
aldehyde dehydrogenase 1 family member A1
chr 9· Drug metabolism· Pathway candidate - ALDH1A2
aldehyde dehydrogenase 1 family member A2
chr 15· Drug metabolism· Pathway candidate - ALDH1A3
aldehyde dehydrogenase 1 family member A3
chr 15· retinoid signaling· Pathway candidate - CRABP2
cellular retinoic acid binding protein 2
chr 1· retinoid signaling· Pathway candidate - CYP26A1
cytochrome P450 family 26 subfamily A member 1
chr 10· retinoid signaling· Pathway candidate - CYP26B1
cytochrome P450 family 26 subfamily B member 1
chr 2· retinoid signaling· Pathway candidate - DHRS3
dehydrogenase/reductase 3
chr 1· retinoid signaling· Pathway candidate
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