Pathway candidateNCBI-verifiedprotein-coding

COX15

cytochrome c oxidase assembly factor COX15

NCBI Gene: 1355 Ensembl GeneCards UniProt: Q7KZN9

Pathway candidate — not linked to PFS or PSSD by any record here

COX15 is in the library because it belongs to the mitochondria & energy family. No study, report or commentary in the corpus names it, so a variant in COX15 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 10 (mitochondrial function and energy). Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Heme A synthase COX15
Function: Catalyzes the second reaction in the biosynthesis of heme A, a prosthetic group of mitochondrial cytochrome c oxidase (CcO). Heme A is synthesized from heme B by two sequential enzymatic reactions catalyzed by heme O synthase (HOS) and heme A synthase (HAS). HAS catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8, in a reaction that involves matrix ferredoxin and ferredoxin reductase. The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A (By similarity).
Pathway: Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1 (By similarity).
Subcellular location: Mitochondrion inner membrane.
Tissue specificity: Predominantly found in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle, heart, and brain.
Associated conditions: Mitochondrial complex IV deficiency, nuclear type 6 (MC4DN6).

Source: UniProtKB/Swiss-Prot Q7KZN9, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Mitochondrial dysfunction and oxidative stress are reported in PFS/PSSD patient work; energy failure plausibly contributes to fatigue, cognitive, and sexual symptoms.

Written for the whole mitochondria & energy family, not for COX15 specifically.

Mentioned in 0 corpus records

No corpus record names COX15 directly yet. It is in the library because it sits in a pathway the corpus tracks (Mitochondria & energy).

Also in mitochondrial function and energy

All 33 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Heme A synthase COX15
Function: Catalyzes the second reaction in the biosynthesis of heme A, a prosthetic group of mitochondrial cytochrome c oxidase (CcO). Heme A is synthesized from heme B by two sequential enzymatic reactions catalyzed by heme O synthase (HOS) and heme A synthase (HAS). HAS catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8, in a reaction that involves matrix ferredoxin and ferredoxin reductase. The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A (By similarity).
Pathway: Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1 (By similarity).
Subcellular location: Mitochondrion inner membrane.
Tissue specificity: Predominantly found in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle, heart, and brain.
Associated conditions: Mitochondrial complex IV deficiency, nuclear type 6 (MC4DN6).