Pathway candidateNCBI-verifiedprotein-coding

DNA2

DNA replication helicase/nuclease 2

NCBI Gene: 1763 Ensembl GeneCards UniProt: P51530

Pathway candidate — not linked to PFS or PSSD by any record here

DNA2 is in the library because it belongs to the mitochondria & energy family. No study, report or commentary in the corpus names it, so a variant in DNA2 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 10 (mitochondrial function and energy). Encodes a member of the DNA2/NAM7 helicase family. The protein is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: DNA replication ATP-dependent helicase/nuclease DNA2
Function (excerpt): Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate.
Subcellular location: Nucleus; Mitochondrion.
Associated conditions: Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 6 (PEOA6); Seckel syndrome 8 (SCKL8); Rothmund-Thomson syndrome 4 (RTS4).

Source: UniProtKB/Swiss-Prot P51530, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Mitochondrial dysfunction and oxidative stress are reported in PFS/PSSD patient work; energy failure plausibly contributes to fatigue, cognitive, and sexual symptoms.

Written for the whole mitochondria & energy family, not for DNA2 specifically.

Mentioned in 0 corpus records

No corpus record names DNA2 directly yet. It is in the library because it sits in a pathway the corpus tracks (Mitochondria & energy).

Also in mitochondrial function and energy

All 33 genes

Browse by family on the gene families page.

Protein reference (UniProt)

Protein: DNA replication ATP-dependent helicase/nuclease DNA2
Function (excerpt): Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate.
Subcellular location: Nucleus; Mitochondrion.
Associated conditions: Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 6 (PEOA6); Seckel syndrome 8 (SCKL8); Rothmund-Thomson syndrome 4 (RTS4).