Pathway candidateNCBI-verifiedprotein-coding

GPX4

glutathione peroxidase 4

NCBI Gene: 2879 Ensembl GeneCards UniProt: P36969

Pathway candidate — not linked to PFS or PSSD by any record here

GPX4 is in the library because it belongs to the mitochondria & energy family. No study, report or commentary in the corpus names it, so a variant in GPX4 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 19 (mitochondrial function and energy). The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Phospholipid hydroperoxide glutathione peroxidase GPX4
Function (excerpt): Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins. Can also reduce cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation. Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species. The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis (By similarity). The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures (By similarity). May be required to protect cells from the toxicity of ingested lipid hydroperoxides (By similarity).
Subcellular location: Mitochondrion; Cytoplasm.
Tissue specificity: Present primarily in testis. Expressed in platelets (at protein level).
Associated conditions: Spondylometaphyseal dysplasia, Sedaghatian type (SMDS).

Source: UniProtKB/Swiss-Prot P36969, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Mitochondrial dysfunction and oxidative stress are reported in PFS/PSSD patient work; energy failure plausibly contributes to fatigue, cognitive, and sexual symptoms.

Written for the whole mitochondria & energy family, not for GPX4 specifically.

Mentioned in 0 corpus records

No corpus record names GPX4 directly yet. It is in the library because it sits in a pathway the corpus tracks (Mitochondria & energy).

Also in mitochondrial function and energy

All 33 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Phospholipid hydroperoxide glutathione peroxidase GPX4
Function (excerpt): Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins. Can also reduce cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation. Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species. The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis (By similarity). The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures (By similarity). May be required to protect cells from the toxicity of ingested lipid hydroperoxides (By similarity).
Subcellular location: Mitochondrion; Cytoplasm.
Tissue specificity: Present primarily in testis. Expressed in platelets (at protein level).
Associated conditions: Spondylometaphyseal dysplasia, Sedaghatian type (SMDS).