Pathway candidateNCBI-verifiedprotein-coding

GPX1

glutathione peroxidase 1

NCBI Gene: 2876 Ensembl GeneCards UniProt: P07203

Pathway candidate — not linked to PFS or PSSD by any record here

GPX1 is in the library because it belongs to the mitochondria & energy family. No study, report or commentary in the corpus names it, so a variant in GPX1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 3 (mitochondrial function and energy). The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Glutathione peroxidase 1
Function: Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis. Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides. In platelets catalyzes the reduction of 12-hydroperoxyeicosatetraenoic acid, the primary product of the arachidonate 12-lipoxygenase pathway.
Subcellular location: Cytoplasm; Mitochondrion.
Tissue specificity: Expressed in platelets (at protein level).

Source: UniProtKB/Swiss-Prot P07203, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Mitochondrial dysfunction and oxidative stress are reported in PFS/PSSD patient work; energy failure plausibly contributes to fatigue, cognitive, and sexual symptoms.

Written for the whole mitochondria & energy family, not for GPX1 specifically.

Mentioned in 0 corpus records

No corpus record names GPX1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Mitochondria & energy).

Also in mitochondrial function and energy

All 33 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Glutathione peroxidase 1
Function: Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis. Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides. In platelets catalyzes the reduction of 12-hydroperoxyeicosatetraenoic acid, the primary product of the arachidonate 12-lipoxygenase pathway.
Subcellular location: Cytoplasm; Mitochondrion.
Tissue specificity: Expressed in platelets (at protein level).