Pathway candidateNCBI-verifiedprotein-coding

GNRH1

gonadotropin releasing hormone 1

NCBI Gene: 2796 Ensembl GeneCards UniProt: P01148

Pathway candidate — not linked to PFS or PSSD by any record here

GNRH1 is in the library because it belongs to the hpg / gonadal axis family. No study, report or commentary in the corpus names it, so a variant in GNRH1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 8 (hpg and gonadal axis). Encodes a preproprotein that is proteolytically processed to generate a peptide that is a member of the gonadotropin-releasing hormone (GnRH) family of peptides. Alternative splicing results in multiple transcript variants, at least one of which is secreted and then cleaved to generate gonadoliberin-1 and GnRH-associated peptide 1.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Progonadoliberin-1
Function: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
Subcellular location: Secreted.
Associated conditions: Hypogonadotropic hypogonadism 12 with or without anosmia (HH12).

Source: UniProtKB/Swiss-Prot P01148, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

HPG-axis signaling and steroid carrier proteins govern testosterone production and bioavailability — central to the endocrine phenotype of post-drug syndromes.

Written for the whole hpg / gonadal axis family, not for GNRH1 specifically.

Mentioned in 0 corpus records

No corpus record names GNRH1 directly yet. It is in the library because it sits in a pathway the corpus tracks (HPG / gonadal axis).

Also in hpg and gonadal axis

All 11 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Progonadoliberin-1
Function: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
Subcellular location: Secreted.
Associated conditions: Hypogonadotropic hypogonadism 12 with or without anosmia (HH12).