Pathway candidateNCBI-verifiedprotein-coding

PRLR

prolactin receptor

NCBI Gene: 5618 Ensembl GeneCards UniProt: P16471

Pathway candidate — not linked to PFS or PSSD by any record here

PRLR is in the library because it belongs to the hpg / gonadal axis family. No study, report or commentary in the corpus names it, so a variant in PRLR is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 5 (hpg and gonadal axis). Encodes a receptor for the anterior pituitary hormone prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor.

Source: NCBI Gene, accessed 2026-10-10; corrected that day, as the page had carried PTP4A3's record.

Protein reference (UniProt)

Protein: Prolactin receptor
Function: This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.
Subcellular location: Membrane; Secreted.
Tissue specificity: Expressed in breast, placenta, kidney, liver and pancreas.
Associated conditions: Multiple fibroadenomas of the breast (MFAB); Hyperprolactinemia (HPRL).

Source: UniProtKB/Swiss-Prot P16471, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

HPG-axis signaling and steroid carrier proteins govern testosterone production and bioavailability — central to the endocrine phenotype of post-drug syndromes.

Written for the whole hpg / gonadal axis family, not for PRLR specifically.

Mentioned in 0 corpus records

No corpus record names PRLR directly yet. It is in the library because it sits in a pathway the corpus tracks (HPG / gonadal axis).

Also in hpg and gonadal axis

All 11 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-10; corrected that day, as the page had carried PTP4A3's record.

Protein reference (UniProt)

Protein: Prolactin receptor
Function: This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.
Subcellular location: Membrane; Secreted.
Tissue specificity: Expressed in breast, placenta, kidney, liver and pancreas.
Associated conditions: Multiple fibroadenomas of the breast (MFAB); Hyperprolactinemia (HPRL).