Pathway candidateNCBI-verifiedprotein-coding

KISS1

KiSS-1 metastasis suppressor

NCBI Gene: 3814 Ensembl GeneCards UniProt: Q15726

Pathway candidate — not linked to PFS or PSSD by any record here

KISS1 is in the library because it belongs to the hpg / gonadal axis family. No study, report or commentary in the corpus names it, so a variant in KISS1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 1 (hpg and gonadal axis). This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Metastasis-suppressor KiSS-1
Function (excerpt): Kisspeptins are ligands for the G protein-coupled receptor KISS1R/GPR54. The hypothalamic KISS1/KISS1R signaling system plays a central role in the regulation of the hypothalamic-pituitary-gonadal reproductive axis by modulating the secretion of gonadotropin-releasing hormone (GnRH) from GnRH neurons. In these neurons, kisspeptin binding to its receptor activates G(q)-dependent signaling, leading to phospholipase C (PLC) activation, and hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2). The subsequent rise in intracellular calcium levels results in the inhibition of inward rectifier potassium channels and activation of TRPC-like cation channels, leading to GnRH neurons depolarization and stimulation (By similarity). In addition to this pathway, kisspeptin also triggers G(q)-independent signaling via beta-arrestin, leading to MAPK cascade activation and ERK1/ERK2 phosphorylation.
Subcellular location: Secreted.
Tissue specificity: High expression in placenta. Expression levels increased in both early placentas and molar pregnancies and are reduced in choriocarcinoma cells. In first trimester trophoblasts is expressed at higher levels than at term of gestation, but only expressed in the villous trophoblast. Also expressed in testis, pancreas, liver, small intestine.
Associated conditions: Hypogonadotropic hypogonadism 13 with or without anosmia (HH13).

Source: UniProtKB/Swiss-Prot Q15726, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

HPG-axis signaling and steroid carrier proteins govern testosterone production and bioavailability — central to the endocrine phenotype of post-drug syndromes.

Written for the whole hpg / gonadal axis family, not for KISS1 specifically.

Mentioned in 0 corpus records

No corpus record names KISS1 directly yet. It is in the library because it sits in a pathway the corpus tracks (HPG / gonadal axis).

Also in hpg and gonadal axis

All 11 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Metastasis-suppressor KiSS-1
Function (excerpt): Kisspeptins are ligands for the G protein-coupled receptor KISS1R/GPR54. The hypothalamic KISS1/KISS1R signaling system plays a central role in the regulation of the hypothalamic-pituitary-gonadal reproductive axis by modulating the secretion of gonadotropin-releasing hormone (GnRH) from GnRH neurons. In these neurons, kisspeptin binding to its receptor activates G(q)-dependent signaling, leading to phospholipase C (PLC) activation, and hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2). The subsequent rise in intracellular calcium levels results in the inhibition of inward rectifier potassium channels and activation of TRPC-like cation channels, leading to GnRH neurons depolarization and stimulation (By similarity). In addition to this pathway, kisspeptin also triggers G(q)-independent signaling via beta-arrestin, leading to MAPK cascade activation and ERK1/ERK2 phosphorylation.
Subcellular location: Secreted.
Tissue specificity: High expression in placenta. Expression levels increased in both early placentas and molar pregnancies and are reduced in choriocarcinoma cells. In first trimester trophoblasts is expressed at higher levels than at term of gestation, but only expressed in the villous trophoblast. Also expressed in testis, pancreas, liver, small intestine.
Associated conditions: Hypogonadotropic hypogonadism 13 with or without anosmia (HH13).