Pathway candidateNCBI-verifiedprotein-coding

SHBG

sex hormone binding globulin

NCBI Gene: 6462 Ensembl GeneCards UniProt: P04278

Pathway candidate — not linked to PFS or PSSD by any record here

SHBG is in the library because it belongs to the hpg / gonadal axis family. No study, report or commentary in the corpus names it, so a variant in SHBG is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 17 (hpg and gonadal axis). Encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The protein transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Sex hormone-binding globulin
Function: Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.
Subcellular location: Secreted.
Tissue specificity: Isoform 1 and isoform 2 are present in liver and testis.

Source: UniProtKB/Swiss-Prot P04278, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

HPG-axis signaling and steroid carrier proteins govern testosterone production and bioavailability — central to the endocrine phenotype of post-drug syndromes.

Written for the whole hpg / gonadal axis family, not for SHBG specifically.

Mentioned in 0 corpus records

No corpus record names SHBG directly yet. It is in the library because it sits in a pathway the corpus tracks (HPG / gonadal axis).

Also in hpg and gonadal axis

All 11 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Sex hormone-binding globulin
Function: Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.
Subcellular location: Secreted.
Tissue specificity: Isoform 1 and isoform 2 are present in liver and testis.