Pathway candidateNCBI-verifiedprotein-coding

SERPINA6

serpin family A member 6

NCBI Gene: 866 Ensembl GeneCards UniProt: P08185

Pathway candidate — not linked to PFS or PSSD by any record here

SERPINA6 is in the library because it belongs to the hpg / gonadal axis family. No study, report or commentary in the corpus names it, so a variant in SERPINA6 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 14 (hpg and gonadal axis). Encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Corticosteroid-binding globulin
Function: Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
Subcellular location: Secreted.
Tissue specificity: Plasma; synthesized in liver. Has also been identified in a number of glycocorticoid responsive cells.
Associated conditions: Corticosteroid-binding globulin deficiency (CBG deficiency).

Source: UniProtKB/Swiss-Prot P08185, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

HPG-axis signaling and steroid carrier proteins govern testosterone production and bioavailability — central to the endocrine phenotype of post-drug syndromes.

Written for the whole hpg / gonadal axis family, not for SERPINA6 specifically.

Mentioned in 0 corpus records

No corpus record names SERPINA6 directly yet. It is in the library because it sits in a pathway the corpus tracks (HPG / gonadal axis).

Also in hpg and gonadal axis

All 11 genes

Browse by family on the gene families page.

Protein reference (UniProt)

Protein: Corticosteroid-binding globulin
Function: Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
Subcellular location: Secreted.
Tissue specificity: Plasma; synthesized in liver. Has also been identified in a number of glycocorticoid responsive cells.
Associated conditions: Corticosteroid-binding globulin deficiency (CBG deficiency).