Pathway candidateNCBI-verifiedprotein-coding

GNRHR

gonadotropin releasing hormone receptor

NCBI Gene: 2798 Ensembl GeneCards UniProt: P30968

Pathway candidate — not linked to PFS or PSSD by any record here

GNRHR is in the library because it belongs to the hpg / gonadal axis family. No study, report or commentary in the corpus names it, so a variant in GNRHR is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 4 (hpg and gonadal axis). Encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Gonadotropin-releasing hormone receptor
Function: Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling.
Subcellular location: Cell membrane.
Tissue specificity: Pituitary, ovary, testis, breast and prostate but not in liver and spleen.
Associated conditions: Hypogonadotropic hypogonadism 7 with or without anosmia (HH7).

Source: UniProtKB/Swiss-Prot P30968, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

HPG-axis signaling and steroid carrier proteins govern testosterone production and bioavailability — central to the endocrine phenotype of post-drug syndromes.

Written for the whole hpg / gonadal axis family, not for GNRHR specifically.

Mentioned in 0 corpus records

No corpus record names GNRHR directly yet. It is in the library because it sits in a pathway the corpus tracks (HPG / gonadal axis).

Also in hpg and gonadal axis

All 11 genes

Browse by family on the gene families page.

Protein reference (UniProt)

Protein: Gonadotropin-releasing hormone receptor
Function: Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling.
Subcellular location: Cell membrane.
Tissue specificity: Pituitary, ovary, testis, breast and prostate but not in liver and spleen.
Associated conditions: Hypogonadotropic hypogonadism 7 with or without anosmia (HH7).