Pathway candidateNCBI-verifiedprotein-coding

MFN1

mitofusin 1

NCBI Gene: 55669 Ensembl GeneCards UniProt: Q8IWA4

Pathway candidate — not linked to PFS or PSSD by any record here

MFN1 is in the library because it belongs to the mitochondria & energy family. No study, report or commentary in the corpus names it, so a variant in MFN1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 3 (mitochondrial function and energy). The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo).

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Mitofusin-1
Function: Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. Membrane clustering requires GTPase activity. It may involve a major rearrangement of the coiled coil domains. Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks (in vitro). Has low GTPase activity.
Subcellular location: Mitochondrion outer membrane; Cytoplasm.
Tissue specificity: Detected in kidney and heart (at protein level). Ubiquitous. Expressed at slightly higher level in kidney and heart. Isoform 2 may be overexpressed in some tumors, such as lung cancers.

Source: UniProtKB/Swiss-Prot Q8IWA4, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Mitochondrial dysfunction and oxidative stress are reported in PFS/PSSD patient work; energy failure plausibly contributes to fatigue, cognitive, and sexual symptoms.

Written for the whole mitochondria & energy family, not for MFN1 specifically.

Mentioned in 0 corpus records

No corpus record names MFN1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Mitochondria & energy).

Also in mitochondrial function and energy

All 33 genes

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Protein reference (UniProt)

Protein: Mitofusin-1
Function: Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. Membrane clustering requires GTPase activity. It may involve a major rearrangement of the coiled coil domains. Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks (in vitro). Has low GTPase activity.
Subcellular location: Mitochondrion outer membrane; Cytoplasm.
Tissue specificity: Detected in kidney and heart (at protein level). Ubiquitous. Expressed at slightly higher level in kidney and heart. Isoform 2 may be overexpressed in some tumors, such as lung cancers.