Pathway candidateNCBI-verifiedprotein-coding

MFN2

mitofusin 2

NCBI Gene: 9927 Ensembl GeneCards UniProt: O95140

Pathway candidate — not linked to PFS or PSSD by any record here

MFN2 is in the library because it belongs to the mitochondria & energy family. No study, report or commentary in the corpus names it, so a variant in MFN2 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 1 (mitochondrial function and energy). Encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Mitofusin-2
Function (excerpt): Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks. Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (By similarity). Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PRKN recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (By similarity).
Subcellular location: Mitochondrion outer membrane.
Tissue specificity: Ubiquitous; expressed at low level. Highly expressed in heart and kidney.
Associated conditions: Charcot-Marie-Tooth disease, axonal, type 2A2B (CMT2A2B); Charcot-Marie-Tooth disease, axonal, type 2A2A (CMT2A2A); Neuropathy, hereditary motor and sensory, 6A, with optic atrophy (HMSN6A); Lipomatosis, multiple symmetric, with or without peripheral neuropathy (MSL).

Source: UniProtKB/Swiss-Prot O95140, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Mitochondrial dysfunction and oxidative stress are reported in PFS/PSSD patient work; energy failure plausibly contributes to fatigue, cognitive, and sexual symptoms.

Written for the whole mitochondria & energy family, not for MFN2 specifically.

Mentioned in 0 corpus records

No corpus record names MFN2 directly yet. It is in the library because it sits in a pathway the corpus tracks (Mitochondria & energy).

Also in mitochondrial function and energy

All 33 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Mitofusin-2
Function (excerpt): Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks. Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (By similarity). Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PRKN recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (By similarity).
Subcellular location: Mitochondrion outer membrane.
Tissue specificity: Ubiquitous; expressed at low level. Highly expressed in heart and kidney.
Associated conditions: Charcot-Marie-Tooth disease, axonal, type 2A2B (CMT2A2B); Charcot-Marie-Tooth disease, axonal, type 2A2A (CMT2A2A); Neuropathy, hereditary motor and sensory, 6A, with optic atrophy (HMSN6A); Lipomatosis, multiple symmetric, with or without peripheral neuropathy (MSL).