Pathway candidateNCBI-verifiedprotein-coding

MPV17

mitochondrial inner membrane protein MPV17

NCBI Gene: 4358 Ensembl GeneCards UniProt: P39210

Pathway candidate — not linked to PFS or PSSD by any record here

MPV17 is in the library because it belongs to the mitochondria & energy family. No study, report or commentary in the corpus names it, so a variant in MPV17 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 2 (mitochondrial function and energy). Encodes a mitochondrial inner membrane protein that is implicated in the metabolism of reactive oxygen species. Mutations in this gene have been associated with the hepatocerebral form of mitochondrial DNA depletion syndrome (MDDS).

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Mitochondrial inner membrane protein Mpv17
Function: Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress, and is involved in mitochondrial homeostasis. Involved in mitochondrial deoxynucleoside triphosphates (dNTP) pool homeostasis and mitochondrial DNA (mtDNA) maintenance. May be involved in the regulation of reactive oxygen species metabolism and the control of oxidative phosphorylation (By similarity).
Subcellular location: Mitochondrion inner membrane.
Tissue specificity: Ubiquitous. Expressed in pancreas, kidney, muscle, liver, lung, placenta, brain and heart.
Associated conditions: Mitochondrial DNA depletion syndrome 6 (MTDPS6); Charcot-Marie-Tooth disease, axonal, type 2EE (CMT2EE).

Source: UniProtKB/Swiss-Prot P39210, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Mitochondrial dysfunction and oxidative stress are reported in PFS/PSSD patient work; energy failure plausibly contributes to fatigue, cognitive, and sexual symptoms.

Written for the whole mitochondria & energy family, not for MPV17 specifically.

Mentioned in 0 corpus records

No corpus record names MPV17 directly yet. It is in the library because it sits in a pathway the corpus tracks (Mitochondria & energy).

Also in mitochondrial function and energy

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Mitochondrial inner membrane protein Mpv17
Function: Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress, and is involved in mitochondrial homeostasis. Involved in mitochondrial deoxynucleoside triphosphates (dNTP) pool homeostasis and mitochondrial DNA (mtDNA) maintenance. May be involved in the regulation of reactive oxygen species metabolism and the control of oxidative phosphorylation (By similarity).
Subcellular location: Mitochondrion inner membrane.
Tissue specificity: Ubiquitous. Expressed in pancreas, kidney, muscle, liver, lung, placenta, brain and heart.
Associated conditions: Mitochondrial DNA depletion syndrome 6 (MTDPS6); Charcot-Marie-Tooth disease, axonal, type 2EE (CMT2EE).