Pathway candidateNCBI-verifiedprotein-coding

MT-ND1

NADH dehydrogenase subunit 1

NCBI Gene: 4535 GeneCards UniProt: P03886

Pathway candidate — not linked to PFS or PSSD by any record here

MT-ND1 is in the library because it belongs to the mitochondria & energy family. No study, report or commentary in the corpus names it, so a variant in MT-ND1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome MT (mitochondrial) (mitochondrial function and energy). Enables NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial electron transport, NADH to ubiquinone and mitochondrial respiratory chain complex I assembly.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: NADH-ubiquinone oxidoreductase chain 1
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Subcellular location: Mitochondrion inner membrane.
Associated conditions: Leber hereditary optic neuropathy (LHON); Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome (MELAS); Alzheimer disease mitochondrial (AD-MT); Type 2 diabetes mellitus (T2D).

Source: UniProtKB/Swiss-Prot P03886, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Mitochondrial dysfunction and oxidative stress are reported in PFS/PSSD patient work; energy failure plausibly contributes to fatigue, cognitive, and sexual symptoms.

Written for the whole mitochondria & energy family, not for MT-ND1 specifically.

Mentioned in 0 corpus records

No corpus record names MT-ND1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Mitochondria & energy).

Also in mitochondrial function and energy

All 33 genes

Browse by family on the gene families page.

Pathway candidateNCBI-verifiedprotein-coding

MT-ND1

NADH dehydrogenase subunit 1

Chromosome MTMitochondria & energy

NCBI Gene: 4535 GeneCards UniProt: P03886

Pathway candidate — not linked to PFS or PSSD by any record here

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: NADH-ubiquinone oxidoreductase chain 1
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Subcellular location: Mitochondrion inner membrane.
Associated conditions: Leber hereditary optic neuropathy (LHON); Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome (MELAS); Alzheimer disease mitochondrial (AD-MT); Type 2 diabetes mellitus (T2D).

Why its pathway is in the library

Mitochondrial dysfunction and oxidative stress are reported in PFS/PSSD patient work; energy failure plausibly contributes to fatigue, cognitive, and sexual symptoms.

Written for the whole mitochondria & energy family, not for MT-ND1 specifically.

Mentioned in 0 corpus records

No corpus record names MT-ND1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Mitochondria & energy).

Also in mitochondrial function and energy

All 33 genes

Browse by family on the gene families page.