Pathway candidateNCBI-verifiedprotein-coding

NCOR2

nuclear receptor corepressor 2

NCBI Gene: 9612 Ensembl GeneCards UniProt: Q9Y618

Pathway candidate — not linked to PFS or PSSD by any record here

NCOR2 is in the library because it belongs to the nuclear receptors family. No study, report or commentary in the corpus names it, so a variant in NCOR2 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 12 (steroid and nuclear hormone receptors). Encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Nuclear receptor corepressor 2
Function: Transcriptional corepressor that mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Acts by recruiting chromatin modifiers, such as histone deacetylases HDAC1, HDAC2 and HDAC3. Required to activate the histone deacetylase activity of HDAC3. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation.
Subcellular location: Nucleus.
Tissue specificity: Ubiquitous. High levels of expression are detected in lung, spleen and brain.

Source: UniProtKB/Swiss-Prot Q9Y618, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Nuclear receptors transduce steroid signals into lasting gene-expression programs; persistent receptor-level remodeling (or silencing) is a leading hypothesis for symptoms that outlast drug exposure.

Written for the whole nuclear receptors family, not for NCOR2 specifically.

Mentioned in 0 corpus records

No corpus record names NCOR2 directly yet. It is in the library because it sits in a pathway the corpus tracks (Nuclear receptors).

Also in steroid and nuclear hormone receptors

All 41 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Nuclear receptor corepressor 2
Function: Transcriptional corepressor that mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Acts by recruiting chromatin modifiers, such as histone deacetylases HDAC1, HDAC2 and HDAC3. Required to activate the histone deacetylase activity of HDAC3. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation.
Subcellular location: Nucleus.
Tissue specificity: Ubiquitous. High levels of expression are detected in lung, spleen and brain.