Pathway candidateNCBI-verifiedprotein-coding

NDUFS1

NADH:ubiquinone oxidoreductase core subunit S1

NCBI Gene: 4719 Ensembl GeneCards UniProt: P28331

Pathway candidate — not linked to PFS or PSSD by any record here

NDUFS1 is in the library because it belongs to the mitochondria & energy family. No study, report or commentary in the corpus names it, so a variant in NDUFS1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 2 (mitochondrial function and energy). The protein encoded by this gene belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for catalysing the entry and efficient transfer of electrons within complex I. Plays a key role in the assembly and stability of complex I and participates in the association of complex I with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes.
Subcellular location: Mitochondrion inner membrane.
Associated conditions: Mitochondrial complex I deficiency, nuclear type 5 (MC1DN5).

Source: UniProtKB/Swiss-Prot P28331, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Mitochondrial dysfunction and oxidative stress are reported in PFS/PSSD patient work; energy failure plausibly contributes to fatigue, cognitive, and sexual symptoms.

Written for the whole mitochondria & energy family, not for NDUFS1 specifically.

Mentioned in 0 corpus records

No corpus record names NDUFS1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Mitochondria & energy).

Also in mitochondrial function and energy

All 33 genes

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Protein reference (UniProt)

Protein: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for catalysing the entry and efficient transfer of electrons within complex I. Plays a key role in the assembly and stability of complex I and participates in the association of complex I with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes.
Subcellular location: Mitochondrion inner membrane.
Associated conditions: Mitochondrial complex I deficiency, nuclear type 5 (MC1DN5).