Pathway candidateNCBI-verifiedprotein-coding

NDUFS2

NADH:ubiquinone oxidoreductase core subunit S2

NCBI Gene: 4720 Ensembl GeneCards UniProt: O75306

Pathway candidate — not linked to PFS or PSSD by any record here

NDUFS2 is in the library because it belongs to the mitochondria & energy family. No study, report or commentary in the corpus names it, so a variant in NDUFS2 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 1 (mitochondrial function and energy). The protein encoded by this gene is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I). Mammalian mitochondrial complex I is composed of at least 43 different subunits, 7 of which are encoded by the mitochondrial genome, and the rest are the products of nuclear genes.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I. Essential for the assembly of complex I (By similarity). Redox-sensitive, critical component of the oxygen-sensing pathway in the pulmonary vasculature which plays a key role in acute pulmonary oxygen-sensing and hypoxic pulmonary vasoconstriction. Plays an important role in carotid body sensing of hypoxia (By similarity). Essential for glia-like neural stem and progenitor cell proliferation, differentiation and subsequent oligodendrocyte or neuronal maturation (By similarity).
Subcellular location: Mitochondrion inner membrane.
Associated conditions: Mitochondrial complex I deficiency, nuclear type 6 (MC1DN6); Leber-like hereditary optic neuropathy, autosomal recessive 2 (LHONAR2).

Source: UniProtKB/Swiss-Prot O75306, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Mitochondrial dysfunction and oxidative stress are reported in PFS/PSSD patient work; energy failure plausibly contributes to fatigue, cognitive, and sexual symptoms.

Written for the whole mitochondria & energy family, not for NDUFS2 specifically.

Mentioned in 0 corpus records

No corpus record names NDUFS2 directly yet. It is in the library because it sits in a pathway the corpus tracks (Mitochondria & energy).

Also in mitochondrial function and energy

All 33 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I. Essential for the assembly of complex I (By similarity). Redox-sensitive, critical component of the oxygen-sensing pathway in the pulmonary vasculature which plays a key role in acute pulmonary oxygen-sensing and hypoxic pulmonary vasoconstriction. Plays an important role in carotid body sensing of hypoxia (By similarity). Essential for glia-like neural stem and progenitor cell proliferation, differentiation and subsequent oligodendrocyte or neuronal maturation (By similarity).
Subcellular location: Mitochondrion inner membrane.
Associated conditions: Mitochondrial complex I deficiency, nuclear type 6 (MC1DN6); Leber-like hereditary optic neuropathy, autosomal recessive 2 (LHONAR2).