Pathway candidateNCBI-verifiedprotein-coding

NR0B1

nuclear receptor subfamily 0 group B member 1

NCBI Gene: 190 Ensembl GeneCards UniProt: P51843

Pathway candidate — not linked to PFS or PSSD by any record here

NR0B1 is in the library because it belongs to the nuclear receptors family. No study, report or commentary in the corpus names it, so a variant in NR0B1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome X (steroid and nuclear hormone receptors). Encodes a protein that contains a DNA-binding domain. The protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Nuclear receptor subfamily 0 group B member 1
Function: Nuclear receptor that lacks a DNA-binding domain and acts as a corepressor that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity).
Subcellular location: Nucleus; Cytoplasm.
Associated conditions: Adrenal hypoplasia, congenital (AHC); 46,XY sex reversal 2 (SRXY2).

Source: UniProtKB/Swiss-Prot P51843, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Nuclear receptors transduce steroid signals into lasting gene-expression programs; persistent receptor-level remodeling (or silencing) is a leading hypothesis for symptoms that outlast drug exposure.

Written for the whole nuclear receptors family, not for NR0B1 specifically.

Mentioned in 0 corpus records

No corpus record names NR0B1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Nuclear receptors).

Also in steroid and nuclear hormone receptors

All 41 genes

Browse by family on the gene families page.

Protein reference (UniProt)

Protein: Nuclear receptor subfamily 0 group B member 1
Function: Nuclear receptor that lacks a DNA-binding domain and acts as a corepressor that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity).
Subcellular location: Nucleus; Cytoplasm.
Associated conditions: Adrenal hypoplasia, congenital (AHC); 46,XY sex reversal 2 (SRXY2).