Pathway candidateNCBI-verifiedprotein-coding

NR3C2

nuclear receptor subfamily 3 group C member 2

NCBI Gene: 4306 Ensembl GeneCards UniProt: P08235

Pathway candidate — not linked to PFS or PSSD by any record here

NR3C2 is in the library because it belongs to the nuclear receptors family. No study, report or commentary in the corpus names it, so a variant in NR3C2 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 4 (steroid and nuclear hormone receptors). Encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Mineralocorticoid receptor
Function: Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.
Subcellular location: Cytoplasm; Nucleus; Endoplasmic reticulum membrane.
Tissue specificity: Ubiquitous. Highly expressed in distal tubules, convoluted tubules and cortical collecting duct in kidney, and in sweat glands. Detected at lower levels in cardiomyocytes, in epidermis and in colon enterocytes.
Associated conditions: Pseudohypoaldosteronism 1, autosomal dominant (PHA1A); Early-onset hypertension with severe exacerbation in pregnancy (EOHSEP).

Source: UniProtKB/Swiss-Prot P08235, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Nuclear receptors transduce steroid signals into lasting gene-expression programs; persistent receptor-level remodeling (or silencing) is a leading hypothesis for symptoms that outlast drug exposure.

Written for the whole nuclear receptors family, not for NR3C2 specifically.

Mentioned in 0 corpus records

No corpus record names NR3C2 directly yet. It is in the library because it sits in a pathway the corpus tracks (Nuclear receptors).

Also in steroid and nuclear hormone receptors

All 41 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Mineralocorticoid receptor
Function: Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.
Subcellular location: Cytoplasm; Nucleus; Endoplasmic reticulum membrane.
Tissue specificity: Ubiquitous. Highly expressed in distal tubules, convoluted tubules and cortical collecting duct in kidney, and in sweat glands. Detected at lower levels in cardiomyocytes, in epidermis and in colon enterocytes.
Associated conditions: Pseudohypoaldosteronism 1, autosomal dominant (PHA1A); Early-onset hypertension with severe exacerbation in pregnancy (EOHSEP).