Pathway candidateNCBI-verifiedprotein-coding

OPA1

OPA1 mitochondrial dynamin like GTPase

NCBI Gene: 4976 Ensembl GeneCards UniProt: O60313

Pathway candidate — not linked to PFS or PSSD by any record here

OPA1 is in the library because it belongs to the mitochondria & energy family. No study, report or commentary in the corpus names it, so a variant in OPA1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 3 (mitochondrial function and energy). The protein encoded by this gene is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. The protein localizes to the inner mitochondrial membrane and helps regulate mitochondrial stability and energy output.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Dynamin-like GTPase OPA1, mitochondrial
Function (excerpt): Dynamin-related GTPase that is essential for normal mitochondrial morphology by mediating fusion of the mitochondrial inner membranes, regulating cristae morphology and maintaining respiratory chain function. Exists in two forms: the transmembrane, long form (Dynamin-like GTPase OPA1, long form; L-OPA1), which is tethered to the inner mitochondrial membrane, and the short soluble form (Dynamin-like GTPase OPA1, short form; S-OPA1), which results from proteolytic cleavage and localizes in the intermembrane space. Both forms (L-OPA1 and S-OPA1) cooperate to catalyze the fusion of the mitochondrial inner membrane. The equilibrium between L-OPA1 and S-OPA1 is essential: excess levels of S-OPA1, produced by cleavage by OMA1 following loss of mitochondrial membrane potential, lead to an impaired equilibrium between L-OPA1 and S-OPA1, inhibiting mitochondrial fusion. The balance between L-OPA1 and S-OPA1 also influences cristae shape and morphology (By similarity).
Subcellular location: Mitochondrion inner membrane; Mitochondrion intermembrane space.
Tissue specificity: Highly expressed in retina. Also expressed in brain, testis, heart and skeletal muscle. Low levels of all isoforms expressed in a variety of tissues.
Associated conditions: Optic atrophy 1 (OPA1); Optic atrophy plus syndrome (DOA+); Behr syndrome (BEHRS); Mitochondrial DNA depletion syndrome 14B, cardioencephalomyopathic type (MTDPS14B); Mitochondrial DNA depletion syndrome 14A, encephalomyopathic type (MTDPS14A).

Source: UniProtKB/Swiss-Prot O60313, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Mitochondrial dysfunction and oxidative stress are reported in PFS/PSSD patient work; energy failure plausibly contributes to fatigue, cognitive, and sexual symptoms.

Written for the whole mitochondria & energy family, not for OPA1 specifically.

Mentioned in 0 corpus records

No corpus record names OPA1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Mitochondria & energy).

Also in mitochondrial function and energy

All 33 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Dynamin-like GTPase OPA1, mitochondrial
Function (excerpt): Dynamin-related GTPase that is essential for normal mitochondrial morphology by mediating fusion of the mitochondrial inner membranes, regulating cristae morphology and maintaining respiratory chain function. Exists in two forms: the transmembrane, long form (Dynamin-like GTPase OPA1, long form; L-OPA1), which is tethered to the inner mitochondrial membrane, and the short soluble form (Dynamin-like GTPase OPA1, short form; S-OPA1), which results from proteolytic cleavage and localizes in the intermembrane space. Both forms (L-OPA1 and S-OPA1) cooperate to catalyze the fusion of the mitochondrial inner membrane. The equilibrium between L-OPA1 and S-OPA1 is essential: excess levels of S-OPA1, produced by cleavage by OMA1 following loss of mitochondrial membrane potential, lead to an impaired equilibrium between L-OPA1 and S-OPA1, inhibiting mitochondrial fusion. The balance between L-OPA1 and S-OPA1 also influences cristae shape and morphology (By similarity).
Subcellular location: Mitochondrion inner membrane; Mitochondrion intermembrane space.
Tissue specificity: Highly expressed in retina. Also expressed in brain, testis, heart and skeletal muscle. Low levels of all isoforms expressed in a variety of tissues.
Associated conditions: Optic atrophy 1 (OPA1); Optic atrophy plus syndrome (DOA+); Behr syndrome (BEHRS); Mitochondrial DNA depletion syndrome 14B, cardioencephalomyopathic type (MTDPS14B); Mitochondrial DNA depletion syndrome 14A, encephalomyopathic type (MTDPS14A).