Pathway candidateNCBI-verifiedprotein-coding

POLG

DNA polymerase gamma, catalytic subunit

NCBI Gene: 5428 Ensembl GeneCards UniProt: P54098

Pathway candidate — not linked to PFS or PSSD by any record here

POLG is in the library because it belongs to the mitochondria & energy family. No study, report or commentary in the corpus names it, so a variant in POLG is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 15 (mitochondrial function and energy). Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: DNA polymerase subunit gamma-1
Function (excerpt): Catalytic subunit of DNA polymerase gamma solely responsible for replication of mitochondrial DNA (mtDNA). Replicates both heavy and light strands of the circular mtDNA genome using a single-stranded DNA template, RNA primers and the four deoxyribonucleoside triphosphates as substrates. Has 5' -> 3' polymerase activity. Functionally interacts with TWNK and SSBP1 at the replication fork to form a highly processive replisome, where TWNK unwinds the double-stranded DNA template prior to replication and SSBP1 covers the parental heavy strand to enable continuous replication of the entire mitochondrial genome. A single nucleotide incorporation cycle includes binding of the incoming nucleotide at the insertion site, a phosphodiester bond formation reaction that extends the 3'-end of the primer DNA, and translocation of the primer terminus to the post-insertion site.
Subcellular location: Mitochondrion; Mitochondrion matrix, mitochondrion nucleoid.
Associated conditions: Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 1 (PEOA1); Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive, 1 (PEOB1); Sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO); Mitochondrial DNA depletion syndrome 4A (MTDPS4A); Mitochondrial DNA depletion syndrome 4B (MTDPS4B); Leigh syndrome (LS); Spinocerebellar ataxia with epilepsy (SCAE).

Source: UniProtKB/Swiss-Prot P54098, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Mitochondrial dysfunction and oxidative stress are reported in PFS/PSSD patient work; energy failure plausibly contributes to fatigue, cognitive, and sexual symptoms.

Written for the whole mitochondria & energy family, not for POLG specifically.

Mentioned in 0 corpus records

No corpus record names POLG directly yet. It is in the library because it sits in a pathway the corpus tracks (Mitochondria & energy).

Also in mitochondrial function and energy

All 33 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: DNA polymerase subunit gamma-1
Function (excerpt): Catalytic subunit of DNA polymerase gamma solely responsible for replication of mitochondrial DNA (mtDNA). Replicates both heavy and light strands of the circular mtDNA genome using a single-stranded DNA template, RNA primers and the four deoxyribonucleoside triphosphates as substrates. Has 5' -> 3' polymerase activity. Functionally interacts with TWNK and SSBP1 at the replication fork to form a highly processive replisome, where TWNK unwinds the double-stranded DNA template prior to replication and SSBP1 covers the parental heavy strand to enable continuous replication of the entire mitochondrial genome. A single nucleotide incorporation cycle includes binding of the incoming nucleotide at the insertion site, a phosphodiester bond formation reaction that extends the 3'-end of the primer DNA, and translocation of the primer terminus to the post-insertion site.
Subcellular location: Mitochondrion; Mitochondrion matrix, mitochondrion nucleoid.
Associated conditions: Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 1 (PEOA1); Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive, 1 (PEOB1); Sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO); Mitochondrial DNA depletion syndrome 4A (MTDPS4A); Mitochondrial DNA depletion syndrome 4B (MTDPS4B); Leigh syndrome (LS); Spinocerebellar ataxia with epilepsy (SCAE).