PPARD
peroxisome proliferator activated receptor delta
Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome 6 (steroid and nuclear hormone receptors). Encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. The protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
Peroxisome proliferator-activated receptor delta
- Function
Ligand-activated transcription factor key mediator of energy metabolism in adipose tissues. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.
- Subcellular location
Nucleus.
- Tissue specificity
Ubiquitous with maximal levels in placenta and skeletal muscle.
Source: UniProtKB/Swiss-Prot Q03181, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
Nuclear receptors transduce steroid signals into lasting gene-expression programs; persistent receptor-level remodeling (or silencing) is a leading hypothesis for symptoms that outlast drug exposure.
Written for the whole nuclear receptors family, not for PPARD specifically.
Mentioned in 0 corpus records
No corpus record names PPARD directly yet. It is in the library because it sits in a pathway the corpus tracks (Nuclear receptors).
Also in steroid and nuclear hormone receptors
All 41 genes- ARPowers
androgen receptor
chr X· Nuclear receptors· 41 records - ESR1
estrogen receptor 1
chr 6· Nuclear receptors· 1 record - ESR2
estrogen receptor 2
chr 14· Nuclear receptors· Pathway candidate - FOXA1
forkhead box A1
chr 14· Nuclear receptors· Pathway candidate - HNF4A
hepatocyte nuclear factor 4 alpha
chr 20· Nuclear receptors· Pathway candidate - HNF4G
hepatocyte nuclear factor 4 gamma
chr 8· Nuclear receptors· Pathway candidate - NCOA1
nuclear receptor coactivator 1
chr 2· Nuclear receptors· Pathway candidate - NCOA2
nuclear receptor coactivator 2
chr 8· Nuclear receptors· Pathway candidate
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